Publications

publications

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‘*’ and ‘#’ indicate shared authorship and (co-)corresponding authorship respectively

2019

59. Crystal structure of the TreS-Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteria
Kermani, A. A., Roy, R. Gopalasingam, G., Kocurek, K. I. and Patel, T. R., Alderwick, L., Besra, G. S. and Fütterer, K.
Journal of Biological Chemistry (2019) in press PubMed

58. Microscale Thermophoresis: Warming up to a New Biomolecular Interaction Technique
Mrozowich, T., Meier-Stephenson, V. and Patel, T. R.#
The Biochemist (2019) 41, 2, 14-17 PubMed

57. A cholesterol analogue induces an oligomeric reorganization of VDAC
Ferens, F., Patel, T. R., Orris, G., Court, D. and Stetefeld, J.
Biophysical Journal  (2019) 116, 847-859 PubMed

56. Proceedings of the Canadian Association for HIV Research – Canadian Foundation for Infectious Diseases Professional Development Workshop for Viral Researchers
Patel, T. R.# , Fowke, K., Matejcic, A., Evans, D. H., Grandvaux, N., Halperin, S. A., MacDonald, N. E., van Marle, G. and Cooper, C.
Journal of the Association of Medical Microbiology and Infectious Disease Canada (2019) in press DOI

2018

55. Comprehensive analysis of hepatitis B virus promoter region mutations
Meier-Stephenson, V., Bremner, WRT, Dalton CS, van Marle, G., Coffin, C. S. and Patel, T. R.#.
Viruses (2018) 10, 603 PubMed

54. Structural Studies of Macromolecules in Solution using Small Angle X-Ray Scattering
Mrozowich, T., McLennan, S., Overduin, M. and Patel, T. R.#
Journal of Visualized Experiments (2018) in press PubMed

53. The role of zyxin in regulation of malignancies
Kotb, A., Hyndman, E. and Patel, T. R.#
Heliyon (2018) 4, e00695 PubMed

52. Non-coding RNAs in virology: an RNA genomics approach
Isaac, C., Patel, T. R. and Zovoilios., A.
Biotechnology and Genetic Engineering Reviews (2018) 34, 90-106 PubMed

51. Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge
Meier, M., Moya, A., Krahn, N., McDougal, M., McRae, E.K.S., Booy, E.P.,Patel, T. R. McKenna, S. A. and Stetefeld, J.
Nucleic Acids Research (2018) 46, 5319-5331 PubMed

50. Viral Proteins Targeting Host Protein Kinase R to Evade an Innate Immune Response: A Mini Review
Dznanovic, E., McKenna, S. A. and Patel, T. R.#
Biotechnology and Genetic Engineering Reviews (2018) 34, 33-59 PubMed

49. DEAD-box helicases: the Yin and Yang roles in viral infections
Meier-Stephenson, V., Mrozowich, T., Pham, M. and Patel, T. R.#
Biotechnology and Genetic Engineering Reviews (2018) 34, 3-32 PubMed

48. Interaction studies of a protein and carbohydrate system using an integrated approach: a case study of miniagrin – heparin system
Patel, T. R.# Besong, T. M., Meier, M., McEleney, K., Harding, S. E., Winzor, D. J. and Stetefeld, J.
European Biophysics Journal (2018) 47, 751-759 PubMed

2017

47. Nano-scale assembly of high-mobility group AT-hook 2a protein with DNA replication fork.
Krahn, N. Meier, M., To, V., Booy, E. P., McEleney, K., O’Neil, J. McKenna, S. A., Patel, T. R.# and Stetefeld, J.
Biophysical Journal (2017) 113, 2609-2620 PubMed

46. Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition.
Dzananovic, E., Astha., Chojnowski, G., Deo, S., Booy, E. P., McEleney, K., Bujnicki, J. M., Booy, E. P., Bujnicki, J. M., Patel, T. R.# and McKenna, S. A.
PLoS One (2017) 12, e0186849, 1-21 PubMed

45. Allowance for radial dilution in evaluating the concentration dependence of sedimentation coefficients for globular proteins.
Patel, T. R.#, Winzor, D. J. and Scott, D. J.
European Biophysics Journal (2018) 47, 751-759 PubMed

44. Intrinsic disorder in the partitioning protein KorB persists after cooperative complex formation with operator DNA and KorA.
Hyde, E. I., Callow, P., Rajesekar K. V., Timmins, P., Patel, T. R., Siligardi, G., Hussain, R., White, S. A., Thomas, C. M., and Scott, D. J.
Biochemical Journal (2017) 474, 3121–3135 PubMed

43. Structural Studies of RNA-protein Complexes: A Hybrid Approach Involving Hydrodynamics, Scattering, and Computational Methods.
Patel, T. R.#, Chojnowski, G., A., Koul, A., McKenna, S. A. and Bujnicki, J. M.
Methods (2017) 118-119, 146-162 PubMed

42. Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity.
Krahn, N., Spearman, M, Meier, M., Spearman, M., Dorion-Thibaudeau, J., McDougall, M., Patel, T. R., De Crescenzo, G., Durocher, Y., Stetefeld, J. and Butler, M.
European Journal of Pharmaceutical Sciences (2017) 96, 428-439 PubMed

2016

41.Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes.
Reuten R.*, Patel, T. R.*, McDougall, M., Rama, N., Nikodemus, D., Gibert, B., Delcros, J., Prein, C., Meier, M., Metzger, S., Zhou, Z., Kaltenberg, J., McKee, K. K., Bald, T., Tüting, T., Zigrino, P., Djonov, V., Bloch, W, Clausen-Schaumann, H., Poschl, E., Yurchenco, P. D., Ehrba, M., Mehlen, P., Stetefeld, J. and Koch, M.
Nature Communications (2016) 7, 13515, 1-17 PubMed

40. Dynamic Light Scattering: A practical guide and applications in biomedical sciences.
Stetefeld, J., McKenna, S. A. and Patel, T. R.#
Biophysical Reviews (2016) 8, 409–427 DOI

39. Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans.
Gillis, R. B., Adams, G. G., Besong, T. M., Machová, E., Ebringerova, A., Rowe, A. J., Harding S. E. and Patel, T. R.#
European Biophysics Journal (2016), 1-11 PubMed

38. LAR protein tyrosine phosphatase regulates focal adhesions via CDK1.
Sarhan, A. R., Patel, T. R., Cowell, A. R., Tomlinson, M. G., Hellberg, C., Heath, J. K., Cunningham, D. L. and Hotchin, N. A.
Journal of Cell Science (2016) 129, 2962-2971 PubMed

37. Regulation of platelet derived growth factor signaling by leukocyte common antigen-related (LAR) protein tyrosine phosphatase: A quantitative phosphoproteomics study.
Sarhan, A. R., Patel, T. R., Creese, A. J., Tomlinson, M. G., Hellberg, C., Heath, J. K., Hotchin, N. A. and Cunningham, D. L.
Molecular & Cellular Proteomics (2016) 15, 1823-1836 PubMed

36. Maltose-Binding Protein (MBP), a secretion-enhancing tag for mammalian protein expression systems.
Reuten, R., Nikodemus, D., Oliveria, M. B., Patel, T. R., Brachvogel, B., Breloy, I., Stetefeld, J. and Koch, M.
PLoS One (2016) 1(3):e0152386 PubMed

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35. Structural decoding of the Netrin-1-UNC5 interaction and its therapeutical implications in cancers.
Grandina, M., Meier, M., Delcrosa, J. G., Nikodemus, D., Reuten, R., Patel, T. R., Goldschneider, D., Orriss, G., Krahn, N., Boussouar, A., Abes, R., Dean, Y., Neves, D., Bernet, A., Depil, S., Schneiders, F., Poole, K., Dante, R., Koch, M., Mehlen, P. and Stetefeld, J.
Cancer Cell (2016) 29, 175-185 PubMed

34. Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction.
Patel, T. R.#, Nikodemus, D., Reuten, R., Besong, T. M., Meier, M., Winzor, D. J., Koch, M. and Stetefeld, J.
Matrix Biology (2016) 49, 93-105 PubMed

33. Analytical ultracentrifugation: A versatile tool for the characterisation of macromolecular complexes in solution.
Patel, T. R.#, Winzor, D. J. and Scott, D. J.
Methods (2016) 95, 55-61 PubMed

2015

32. Biophysical characterization of G-quadruplex recognition in the PITX1 mRNA by the specificity domain of the helicase RHAU.
Ayiro, E. O., Booy, E. P., Patel, T. R., Dzananovic, E., McRae, E. K., Meier, M., McEleney, K., Stetefeld, J. and McKenna, S. A.
PLoS ONE (2015) 10, e0144510 PubMed

 

31. Characterization of the termini of the West Nile virus genome and their interactions with the small isoform of the 2′ 5′-oligoadenylate synthetase family.
Deo, S., Patel, T. R., Chojnowski, G., Koul, A., Dzananovic, E., McEleney, K., Bujnicki, J. M. and McKenna, S. A.
Journal of Structural Biology (2015) 190, 236-249 PubMed

30. The β – lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N acetylmuramic acid (MurNAc)-pentapeptide.
Vadlamani, G., Balcewich, M. D., Patel, T. R., Donald, L, J., Reeve, T. M., Stetefeld, J., Standing, K. G., Vocadlo, D. J. and Mark, B. L.
Journal of Biological Chemistry (2015) 290, 2630-2643 PubMed

2014

29. Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity.
Kumar, S., Žigman, M., Patel, T. R., Trageser, B., Gross, J. C., Rahm, K., Boutros, M., Gradl, D., Steinbeisser, H., Holstein, T., Stetefeld, J. and Özbek, S.
BMC Biology (2014) 12, 44 PubMed

 

28. Activation of 2’ 5’-oligoadenylate synthetase by stem loops at the 5’-end of the West Nile virus genome.
Deo, S., Patel, T. R., Dzananovic, E., Booy, E. P., Zeid, K., McEleney, K., Harding, S. E. and McKenna, S. A.
PLoS ONE (2014) 9, e92545 PubMed

27. Conformational itinerary of Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic acid kinase during its catalytic cycle.
Bacik J. P., Tavassoli. M., Patel, T. R., McKenna, S. A., Vocadlo, D. J., Khajehpour, M. and Mark, B. L.
Journal of Biological Chemistry (2014) 289, 3176-3185 PubMed

26. Solution conformation of adenovirus virus associated RNA-I and its interaction with PKR.
Dzananovic, E.,* Patel, T. R.*, Chojnowski, G., Boniecki, M. J., Deo, S., McEleney, K., Harding, S. E., Bujnicki, J. M. and McKenna, S. A.
Journal of Structural Biology (2014) 185, 48-57 PubMed

25. Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution.
Patel, T. R., Bernards, C., Meier, M., McEleney, K., Winzor, D. J., Koch, M. and Stetefeld, J.
Matrix Biology (2014) 33, 60-67 PubMed

2013

24. Binding of G-quadruplexes to the N-terminal recognition domain of the RNA helicase associated with AU-rich element (RHAU).
Meier, M.,* Patel, T. R.*, Booy, E. P., Marushchak, O., Okun, N., Deo, S., Howard, R., McEleney, K., Harding, S. E., Stetefeld, J. and McKenna, S. A.
Journal of Biological Chemistry (2013) 288, 35014-35027 PubMed

23. C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells.
Glogowska, A., Kunanuvat, U., Stetefeld. J., Patel, T. R., Thanasupawat, T., Krcek, J., Weber, E., Wong, G. W., Bigio, M., Hoang-Hu, C., Hombach-Klonisch, S., Klonisch, T.
The Journal of Pathology (2013) 231, 466-479 PubMed

22. A potential for overestimating the absolute magnitudes of second virial coefficients by small-angle X-ray scattering.
Scott, D. J., Patel, T. R. and Winzor, D. J.
Analytical Biochemistry (2013) 435, 159-165 PubMed

21. Recognition of viral RNA stem-loops by the tandem double-stranded RNA binding domains of PKR.
Dzananovic, E.,* Patel, T. R.*, Deo, S., McEleney, K., Stetefeld, J. and McKenna, S. A.
RNA (2013) 19, 333-344 PubMed

2012

20. Site specific cleavage mediated by MMPs regulates function of agrin.
Patel, T. R., Butler, G., McFarlane, A., Xie, I., Overall, C. M. and Stetefeld, J..
PLoS ONE (2012) 7, e43669 PubMed

19. Determination of a molecular shape for netrin-4 from hydrodynamic and small angle X-ray scattering measurements.
Patel, T. R., Reuten, R., Xiong, S., Meier, M., Winzor, D. J., Koch, M. and Stetefeld, J.
Matrix Biology (2012) 31, 135-140 PubMed

18. The macromolecular state of A-kinase anchoring protein.
Patel, T. R.# and Winzor, D. J.
Journal of Molecular Recognition (2012) 25, 11-14 PubMed

2011

17. Evidence for self-association of a miniaturized version of agrin from hydrodynamic and small-angle X-ray scattering measurements.
Patel, T. R.#, Besong, T. M., Patel, N., Meier, M., Harding, S. E., Winzor, D. J. and Stetefeld, J.
Journal of Physical Chemistry B (2011) 115, 11286-11293 PubMed

 

16. Examination of the discrepancy between size estimates for ovalbumin from small-angle X-ray scattering and other physicochemical measurements.
Scott, D. J., Patel, T. R., Besong, T. M., Stetefeld, J. and Winzor, D. J.
Journal of Physical Chemistry B (2011) 115, 10725-10729 PubMed

15. T-shaped arrangement of the recombinant agrin G3-IgG Fc protein.
Patel, T. R., Meier, M., Li, J. Morris, G., Rowe, A. J. and Stetefeld, J.
Protein Science (2011) 20, 931-940 PubMed

14. Reassessment of the size of the supermolecular state of Dishevelled-3.
Patel, T. R.# and Winzor, D. J.
Journal of Molecular Recognition (2011) 24, 843-846 PubMed

2010

13. Nano-structure of the laminin γ-1 short arm reveals an extended and curved multidomain assembly.
Patel, T. R., Morris, G. A., Zwolanek, D., Keene, D. R., Li, J., Harding, S. E., Koch, M. and Stetefeld, J.
Matrix Biology (2010) 29, 565-572 PubMed

 

12. Absence of a catalytic water confers resistance to the neurotoxin gabaculine.
Orriss, G. L., Patel, T. R., Sorensen, J. and Stetefeld, J.
FASEB Journal (2010) 24, 404-414 PubMed

2009

11.Vimentin coil 1A-A molecular switch involved in the initiation of filament elongation.
Meier, M., Padilla, G. P., Herrmann, H., Wedig, T., Hergt, M., Patel, T. R., Stetefeld, J., Aebi, U. and Burkhard, P.
Journal of Molecular Biology (2009) 390, 245-261 PubMed

 

2008

10. Molecular flexibility of methylcelluloses of differing degree of substitution by combined sedimentation and viscosity analysis.
Patel, T. R., Morris, G. A., Garcia de la Torre, J., Ortega, A., Mischnick, P. and Harding, S. E.
Macromolecular Bioscience (2008) 8, 1108-1115 PubMed

 

09. Pectic polysaccharides from Biophytum petersianum Klotzsch, and their activation of macrophages and dendritic cells.
Inngjerdingen, M., Inngjerdingen, K. T., Patel, T. R., Allen, S., Chen, X., Rolsted, B., Harding, S. E., Michaelsen, T. J., Diallo, D. and Paulsen, B. S.
Glycobiology (2008) 18, 1074-1084 PubMed

08. Global conformation analysis of irradiated xyloglucans.
Patel, T. R., Ebringerová, A., Vodeničarová, M., Velebny, V., Morris, G. A., Ortega, A., Garcia de la Torre, J. and Harding, S. E.
Carbohydrate Polymers (2008) 74, 845-851 DOI

07. Global hydrodynamic analysis of the molecular flexibility of galactomannans.
Morris, G. A., Patel, T. R., Picout, D. R., Ross-Murphy, S. B., Ortega, A., Garcia de la Torre, J. and Harding, S. E.
Carbohydrate Polymers (2008) 72, 356-360 DOI

2007

06. Immunological and structural properties of a pectic polymer from Glinus oppositifolius.
Inngjerdingen, K. T., Patel, T. R., Chen, X., Lennart, K., Allen, S., Morris, G. A., Harding, S. E., Matsumoto, T., Diallo, D., Yamada, H., Michaelsen, T. E., Inngjerdingen, M. and Paulsen, B. S.
Glycobiology (2007) 17, 1299-1310 PubMed

 

05. Weak self-association in a carbohydrate system.
Patel, T. R., Harding, S. E., Ebringerová, A., Deszczynski, M., Hromadkova, Z., Togola, A., Paulsen, B. S., Morris, G. A. and Rowe, A. J.
Biophysical Journal (2007) 93, 741-749 PubMed
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2006

04. Pressure cell assisted solution characterization of galactomannans. 3. Application of analytical ultracentrifugation techniques.
Patel, T. R., Picout, D. R., Harding, S. E. and Ross-Murphy, S. B.
Biomacromolecules (2006) 7, 3513- 3520 PubMed

03. Resonance energy transfer between green fluorescent protein variants: complexities revealed with myosin fusion proteins.
Zeng, W., Seward, H. E., Málnási-Csizmadia, A., Wakelin, S., Woolley, R. J., Cheema, G. S., Basran, J., Patel, T. R., Rowe, A. J. and Bagshaw, C. R.
Biochemistry (2006) 45, 10482-10491 PubMed

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02. Damaged starch characterisation by ultracentrifugation.
Tester, R. F., Patel, T. R. and Harding, S. E.
Carbohydrate Research (2006) 341, 130-137 PubMed

01. Structures and structure-activity relationships of three mitogenic and complement fixing pectic arabinogalactans from the malian antiulcer plants Cochlospermum tinctorium A. Rich and Vernonia kotschyana Sch. Bip. ex Walp.
Nergard, C. S., Kiyohara, H., Reynolds, J. C., Thomas-Oates, J. E., Matsumoto, T., Yamada, H., Patel, T. R., Petersen. D., Michaelsen, T. E., Diallo, D., Paulsen, S. B.
Biomacromolecules (2006) 7, 71-79 PubMed