Publications

104.

Structural dynamics of dengue virus UTRs and their cyclization

Robinson ZE*, Pereira HS*, D’Souza MH* and Patel TR#

Biophysical Journal, revision requested

View Article

103.

Global distribution of microbial carrageenan foraging pathways reveals latent traits within the genetic dark matter of ruminant intestinal microbiomes

Tingley J*, Andersen T, Mihalynuk L, Xing X, Low K, Whiteside D, Altshuler I, Jujihara N, Shearer A, Klassen L*, Serin S, Smith E, Reintjes G, Patel TR, Boraston A, Hagen L, Pope P#

Nature Communications, revision requested

View Article

102.

Zyxin directly binds to chromosomal DNA and regulates the expression of mitochondrial pseudogenes, mitochondrial integrity and apoptosis in prostate cancer

Siddiqui MQ*, Wojewodzic MW, Sanghvi S, Pereira HS*, Vasudeva G*, Meadows K*, Prajapati R*, Geeraert M*, Badmalia MD, Owens RJ, Singh H and Patel TR#

Biochemistry and Cell Biology

View Article

101.

Solution Structure Determination and Biophysical Studies of 7SK RNP and 7SL SRP RNAs

D’Souza MH*, Pereira HS*, Tersteeg S*, Vasudeva G*, Siddiqui MQ*, Agunlejika,T*, Kerr L*, Girodat D and Patel TR#

RNA

View Article

100.

Discovery of functional factor-less internal ribosome entry site-like structures through virome mining

Champagain S, Salcedo-Porras N, Abdolahzadeh A, Zhang Y, Pereira, HS, Flibotte S, Low K, Young C, Wu Y, Wang S, Ishiguro S, Yachie N, Patel TR, Babain A and Jan E

PLOS Pathogens

View Article

99.

Alu RNA pseudoknot alterations influence SRP9/SRP14 association

Gussakovsky D, Brown MJF, Pereira HS*, Meier M, Padilla-Meier GP, Black NA, Booy EP, Stetefeld J, Patel TR and McKenna SA#

RNA

View Article

98.

Characterization of Biomolecular Interactions by Biophysical Methods

Demeler A*, Bosco J, Sydor MJ, Nemetchek M, Mortezazadeh S, Kerr L, Bird S, Gabdullina R, Yates-Hansen C, McClelland LJ, Voronina E, Patel TR, Demeler B#

Analytical Biochemistry

View Article

97.

Development of Low-Cost In-House Assays for Quantitative Detection of HBsAg, HBeAg, and HBV DNA to Enhance Hepatitis B Virus Diagnostics and Antiviral Screening in Resource-Limited Settings

D'souza S*, Al-Yasiri L, Chen A, Boghici DT, van Marle G, Corcoran JA, Patel TR and Coffin, CS#

Pathogens

View Article

96.

Suppressing Tymovirus replication in plants using a variant of ubiquitin

De Silva A, Kim K, Weiland J, Hwang J, Chung J, Pereira HS*. Patel TR, Teyra J, Patel A, Mira MM, Khajehpour M, Bolton M, Stasolla C, Sidhu SS. and Mark BL#

Plos Pathogens

View Article

95.

Regional Medical Campuses in Canada: Exploring the Landscape of Current and Proposed Campuses

Johnston A#, Bell A, Penner K, Patel TR and Perez G

Journal of Regional Medical Campuses

View Article

94.

In vitro and ex vivo metabolism of chemically diverse fructans by bovine rumen Bifidobacterium and Lactobacillus species

King ML*, Xing X, Reintjes G, Klassen L*, Low KE, Alexander TW, Waldner M, Patel TR, and Abbott DW#

Animal Microbiome

View Article

93.

Analysis of the interlink between glucose-6-phosphate dehydrogenase (G6PD) and lung cancer through multi-omic databases

Thakor P, Siddiqui MQ and Patel TR#

Heliyon

View Article

92.

Assessment of HBV variants and novel viral and immune biomarkers in chronic 2 hepatitis B patients with metabolic-dysfunction associated steatotic liver disease

Patel NH, Lucko A, Vachon A, Doucette KE, Ramji A, Sycuro L, Patel TR, Chadee K, Raman M, van Marle G, Osiowy C. and Coffin CS#

Journal of Viral Hepatitis

View Article

91.

Factor-dependent internal ribosome entry site and -1 programmed frameshifting signal in the Bemisia-associated dicistrovirus 2

Chen Y, Chapagain, S., Chien J, Pereira HS*, Patel TR, Nagata A and Jan E#

Viruses

View Article

90.

Development of a single-domain antibody to target a G-quadruplex located on the hepatitis B virus covalently closed circular DNA Genome

Figueroa GB*, D'souza S*, Pereira HS*, Vasudeva G*, Figueroa GB*, Robinson ZE*, Badmalia MD*, Meier-Stephenson V*, Corcoran JA., van Marle G, Ni Y, Urban S, Coffin CS, and Patel TR.#

Journal of Medical Virology

View Article

89.

Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

Mazeaud C, Pfister S, Owen JE, Pereira HS*, Robinson ZE*, Anton A, Bemis CL, Sow AA, Patel TR, Neufeldt CJ, Scaturro P. and Chatel-Chaix L#

eLife

View Article

88.

tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut

Krahn N, Zhang J, Melnikov SG, Tharp JM, Villa A, Patel A, Howard RJ, Gabir H, Patel TR, Stetefeld J, Puglisi J and Söll D#

Nucleic Acids Research

View Article

87.

The 3' terminal region of Zika virus RNA contains a conserved G-quadruplex and is unfolded by human DDX17

Gemmill DL*, Nelson CR*, Badmalia MD*, Pereira HS*, Wolfinger MW and Patel TR#

Biochemistry and Cell Biology

View Article

86.

Genomic Mapping and Characterization of G-quadruplexes in Monkeypox Genomes

Pereira HS*, Gemmill DL* Siddique MQ*, Vasudeva G* and Patel TR.#

Journal of Medical Virology

View Article

85.

Investigating RNA-RNA interactions through computational and biophysical analysis

Mrozowich T*, Park SM*, Waldl M, Henrickson A, Tersteeg S*, Nelson CR*, De Klerk A*, Demeler B, Hofacker IL, Wolfinger MT and Patel TR#

Nucleic Acids Research

View Article

84.

A comprehensive review of methods to study lncRNA-protein interactions in solution

Badmalia MD*, Siddiqui MQ*, Pereira HS* and Patel TR#

Biochemical Society Transactions

View Article

83.

Purification and Characterization of Inorganic Pyrophosphatase for in vitro RNA Transcription

Tersteeg S*, Mrozowich T*, Henrickson A, Demeler B, and Patel TR#

Biochemistry and Cell Biology

View Article

82.

Biophysical Characterisation of Human LincRNA-p21 Sense and Antisense Alu Inverted Repeats

D'Souza MD, Mrozowich T*, Badmalia MD*, Geeraert M,* Frederickson A, * Henrickson A, Demeler B, Wolfinger MT and Patel TR#

Nucleic Acids Research

View Article

81.

Targeting Xist with compounds that disrupt RNA structure and X-inactivation

Aguilar R, Spencer KB, Kesner B, Rizvi NF, Badmalia MD*, Mrozowich T*, Mortison JD, Rivera C, Smith GS, Burchard J, Dandliker P, Patel TR, Nickbarg EB, Lee JT

Nature

View Article

80.

Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratox

Rutbeek NR, Rezasoltani H, Patel TR, Khajehpour M and Prehna G

Journal of Biological Chemistry

View Article

79.

Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA

Meier-Stephenson V*, Badmalia M*, Mrozowich T*, Lau KCK, Schultz SK*, Gemmill D*, Osiowy C, van Marle G, Coffin CS and Patel TR#

Journal of Biological Chemistry

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78.

Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins

Siddique MQ*, Badmalia M* and Patel TR#

International Journal of Molecular Sciences

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77.

Human DDX3X unwinds Japanese Encephalitis and Zika viral 5' Terminal Regions

Nelson C, * Mrozowich T,* Gemmill DL,* Park SM,* and Patel TR#

International Journal of Molecular Sciences

View Article

76.

Biophysical Characterisation of G-quadruplex Nucleic Acids Using Top-Down and Bottom-Up Approaches

Meier M, Park SM*, Mao H, Xu B, Bénard L, Schapira M, McKenna SA and Patel TR#

International Journal of Molecular Sciences

View Article

75.

Molecular characterization of the programmed ribosomal frameshifting complex generated by Porcine Reproductive and Respiratory Syndrome Virus

Patel A, Treffers EE, Meier M, Patel TR, Stetefeld J, Snijder EJ and Mark BL#

Journal of Biological Chemistry

View Article

74.

Analytical ultracentrifuge: An ideal tool for characterization of non-coding RNAs

Badmalia M*, Siddique MQ*, Mrozowich T*, Gemmill D* and Patel TR#

European Biophysics Journal

View Article

73.

Molecular Mechanisms of Viral Hepatitis Induced Hepatocellular Carcinoma

D'souza S*, Lau KCK, Coffin CS and Patel TR#

World Journal of Gastroenterology

View Article

72.

Biodefense implications of New-World Hantaviruses

D'Souza MH* and Patel TR#

Frontiers in Bioengineering and Biotechnology

View Article

71.

Structural and hydrodynamic characterization of dimeric human oligoadenylate synthetase 2

Koul A, Gemmill D*, Lubma N, Meier M, Booy EP, Stetefeld J, Patel TR## and McKenna S#

Biophysical Journal

View Article

70.

The biomedical and bioengineering potential of protein nanocompartments

Aubrey D* and Patel TR#

Biotechnology Advances

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69.

Nanoscale structure determination of Murray Valley encephalitis and Powassan virus non-coding RNAs

Mrozowich T*, Henrickson A, Demeler B and Patel TR#

Viruses

View Article

68.

Host transcription factors in Hepatitis B Virus RNA synthesis

Turton KL*, Meier-Stephenson V*, Badmalia MD*, Coffin CS and Patel TR#

Viruses

View Article

67.

Solution structure and oligomeric state of the E. coli glycerol facilitator

Hernando M, Orris G, Perodeau J, Lei S, Ferens F, Patel TR, Stetefeld J, Nieuwkoop AJ and O'Neil J#

Biochimica et Biophysica Acta - Biomembranes

View Article

66.

Canadian Science Meets Parliament: Building Relationships Between Scientists and Policymakers

Zhao J##, Azad MB, Burton C, Crooks VA, Dawson J, Ford AT, Kaida A, Krishnaswamy A, Kouk C, Mah CL, McTaggart M, Moehring A, Robert D, Schulte-Hostedde A, Sparling H, De Vera M, Waterman S and Patel TR#

Science and Public Policy

View Article

65.

Current approaches for RNA labelling to identify RNA-binding proteins

Gemmill D*, D'souza S*, Meier-Stephenson V* and Patel TR#

Biochemistry and Cell Biology

View Article

64.

Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution

Kim DN, Thiel B, Mrozowich T*, Hennelley S, Hofacker I, Patel TR##, Sanbonmatsu K#

Nature Communications

View Article

63.

Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase

Yazdi MM, Saran S, Mrozowich T*, Lehnert C, Patel TR##, Sanders DA##, Palmer DRJ#

Journal of Structural Biology

View Article

62.

Experimental determination of second virial coefficients by small-angle X-ray Scattering: a problem revisited

Mrozowich T*, Winzor DJ, Scott DJ## and Patel TR#

European Biophysics Journal

View Article

61.

Use of molecular crowding for the detection of protein self-association by size-exclusion chromatography

Mrozowich T*, Winzor DJ, Scott DJ and Patel TR#

Analytical Biochemistry

View Article

60.

Solution structure of C. elegans UNC-6: A nematode paralogue of the axon guidance protein netrin-1

Krahn N*, Reuten R, Meier M, Koch M, Stetefeld J# and Patel TR#

Biophysical Journal

View Article

59.

Crystal structure of the TreS-Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteria

Kermani AA, Roy R, Gopalasingam G, Kocurek KI, Patel TR, Alderwick LJ, Besra GS and Fütterer K#

Journal of Biological Chemistry

View Article

58.

Microscale thermophoresis: Warming up to a new biomolecular interaction technique

Mrozowich T*, Meier-Stephenson V* and Patel TR#

The Biochemist

View Article

57.

A cholesterol analog induces an oligomeric reorganization of VDAC

Ferens F, Patel TR, Orriss G, Court D and Stetefeld J#

Biophysical Journal

View Article

56.

Proceedings of the Canadian Association for HIV Research – Canadian Foundation for Infectious Diseases Professional Development Workshop for Viral Researchers

Patel TR##, Fowke K, Matejcic A, Evans DH, Grandvaux N, Halperin SA, MacDonald NE, van Marle G, Richardson S and Cooper C#

Journal of the Association of Medical Microbiology and Infectious Disease

View Article

55.

Comprehensive analysis of hepatitis B virus promoter region mutations

Meier-Stephenson V*, Bremner W, Dalton C, Marle G, Coffin CS and Patel TR#

Viruses

View Article

54.

Structural studies of macromolecules in solution using small angle X-Ray scattering

Mrozowich T*, McLennan S, Overduin MO## and Patel TR#

Journal of Visualized Experiments

View Article

53.

The role of zyxin in regulation of malignancies

Kotb A, Hyndman E and Patel TR#

Heliyon

View Article

52.

Viral proteins targeting host protein kinase R to evade an innate immune response: a mini review

Dznanovic E*, McKenna SA and Patel TR#

Biotechnology and Genetic Engineering Reviews

View Article

51.

DEAD-box helicases: The Yin and Yang roles in viral infections

Meier-Stephenson V*, Mrozowich T*, Pham M* and Patel TR#

Biotechnology and Genetic Engineering Reviews

View Article

50.

Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge

Meier M, Moya A, Krahn N, McDougal M, McRae EKS, Booy, EP, Patel TR, McKenna SA and Stetefeld J#

Nucleic Acids Research

View Article

49.

Non-coding RNAs in Virology: an RNA Genomics Approach

Isaac C, Patel TR, and Zovoilis A#

Biotechnology and Genetic Engineering Reviews

View Article

48.

Interaction studies of a protein and carbohydrate system using an integrated approach: a case study of miniagrin - heparin system

Patel TR##, Besong TMD, Meier M, McEleney K, Harding S and Stetefeld J#

European Biophysics Journal

View Article

47.

Intrinsic disorder in the partitioning protein KorB persists after co-operative complex formation with operator DNA and KorA

Hyde EI, Callow P, Rajesekar KV, Timmins P, Patel TR, Siligardi G, Hussain R, White SA, Thomas CM and Scott DJ#

Biochemical Journal

View Article

46.

Nanoscale assembly of high-mobility group AT-hook 2 protein with DNA replication fork

Krahn N*, Meier M, Booy EP, Vu T, McEleney K, O'Neil J, McKenna SA, Patel TR## and Stetefeld J#

Biophysical Journal

View Article

45.

Allowance for radial dilution in evaluating the concentration dependence of sedimentation coefficients for globular proteins

Patel TR##, Winzor DJ and Scott DJ#

European Biophysics Journal

View Article

44.

Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition

Dzananovic E, Chojnowski G, Deo S, Booy EP, Padilla-Meier, P, McEleney K, Bujnicki JM, Patel TR## and McKenna SA#

PLoS One

View Article

43.

Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity

Krahn N, Spearman M, Meier M, Dorion-Thibaudeau J, McDougall M, Patel TR, De Crescenzo G, Durocher Y, Stetefeld J and Butler M#

European Journal of Pharmaceutical Sciences

View Article

42.

Structural studies of RNA-protein complexes: A hybrid approach involving hydrodynamics, scattering, and computational methods

Patel TR##, Chojnowski GA, Koul A, McKenna SA and Bujnicki JM#

Methods

View Article

41.

Regulation of platelet derived growth factor signaling by leukocyte common antigen-related (LAR) protein tyrosine phosphatase: A quantitative phosphoproteomics study

Sarhan AR, Patel TR, Creese AJ, Tomlinson MG, Hellberg C, Heath JK, Hotchin NA, and Cunningham DL#

Molecular & Cellular Proteomics

View Article

40.

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes

Reuten R, Patel TR, McDougall M, Rama N, Nikodemus D, Gibert B, Delcros J, Prein, C, Meier M, Metzger S, Zhou Z, Kaltenberg J, McKee KK, Bald T, Tüting T, Zigrino P, Djonov V, Bloch W, Clausen-Schaumann H, Poschl E, Yurchenco PD, Ehrba M, Mehlen P, Stetefeld J## and Koch M#

Nature Communications

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39.

Dynamic light scattering: A practical guide and applications in biomedical sciences

Stetefeld J##, McKenna SA and Patel TR#

Biophysical Reviews

View Article

38.

LAR protein tyrosine phosphatase regulates focal adhesions through CDK1

Sarhan AR, Patel TR, Tomlinson MG, Hellberg C, Heath JK, Cunningham DL and Hotchin NA#

Journal of Cell Sciences

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37.

Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans

Gillis RB, Adams GG, Besong TM, Machová E, Ebringerová A, Rowe AJ, Harding SE and Patel TR#

European Biophysics Journal

View Article

36.

Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers

Grandin M, Meier M, Delcros JG, Nikodemus D, Reuten R, Patel TR, Goldschneider D, Orriss G, Krahn N, Boussouar A, Abes R, Dean Y, Neves D, Bernet A, Depil S, Schneiders F, Poole K, Dante R, Koch M, Mehlen P and Stetefeld J#

Cancer Cell

View Article

35.

Maltose-binding protein (MBP), a secretion-enhancing tag for mammalian protein expression systems

Reuten R, Nikodemus D, Oliveira MB, Patel TR, Brachvogel B, Breloy I, Stetefeld J and Koch M#

PLoS One

View Article

34.

Biophysical analysis of a lethal laminin alpha-1 mutation reveals altered self-interaction

Patel TR##, Nikodemus D, Reuten R, Besong TM, Meier M, Winzor DJ, Koch M and Stetefeld J#

Matrix Biology

View Article

33.

The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide

Vadlamani G, Thomas MD, Patel TR, Donald LJ, Reeve TM, Stetefeld J, Standing KG, Vocadlo DJ and Mark BL#

Journal of Biological Chemistry

View Article

32.

Analytical ultracentrifugation: a versatile tool for the characterisation of macromolecular complexes in solution

Patel TR##, Winzor DJ and Scott DJ#

Methods

View Article

31.

Biophysical characterization of G-quadruplex recognition in the PITX1 mRNA by the specificity domain of the helicase RHAU

Ariyo EO, Booy EP, Patel TR, Dzananovic E, McRae EK, Meier M, McEleney K, Stetefeld J and McKenna SA#

PloS One

View Article

30.

Characterization of the termini of the West Nile virus genome and their interactions with the small isoform of the 2' 5' - oligoadenylate synthetase family

Deo S, Patel TR, Chojnowski G, Koul A, Dzananovic E*, McEleney K, Bujnicki JM and McKenna SA#

Journal of Structural Biology

View Article

29.

Solution conformation of Adenovirus virus associated RNA-I and its interaction with PKR

Dzananovic E, Patel TR, Chojnowski G, Boniecki MJ, Deo S*, McEleney K, Harding SE, Bujnicki JM and McKenna SA#

Journal of Structural Biology

View Article

28.

Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity

Kumar S, Žigman M, Patel TR, Trageser B, Gross JC, Rahm K, Boutros M, Gradl D, Steinbeisser H, Holstein T, Stetefeld J and Özbek S#

BMC Biology

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27.

Conformational itinerary of Pseudomonas aeruginosa 1, 6-anhydro-N-acetylmuramic acid kinase during its catalytic cycle

Bacik JP, Tavassoli M, Patel TR, McKenna SA, Vocadlo DJ, Khajehpour M and Mark BL#

Journal of Biological Chemistry

View Article

26.

Activation of 2' 5'-oligoadenylate synthetase by stem loops at the 5′-end of the West Nile virus genome

Deo S, Patel TR, Dzananovic E, Booy EP, Zeid K, McEleney K, Harding SE and McKenna SA#

PloS ONE

View Article

25.

Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution

Patel TR, Bernards C, Meier M, McEleney K, Winzor DJ, Koch M and Stetefeld J#

Matrix Biology

View Article

24.

C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells

Glogowska A, Kunanuvat U, Stetefeld J, Patel TR, Thanasupawat T, Krcek J, Weber E, Wong GW, Del Bigio MR, Hoang-Hu C, Hombach-Klonisch S and Klonisch T#

Journal of Pathology

View Article

23.

A potential for overestimating the absolute magnitudes of second virial coefficients by small-angle X-ray scattering

Scott DJ, Patel TR, and Winzor DJ#

Analytical Biochemistry

View Article

22.

Binding of G-quadruplexes to the N-terminal recognition domain of the RNA helicase associated with AU-rich element (RHAU)

Meier M, Patel TR, Booy EP, Marushchak O, Okun N*, Deo S*, Howard R, McEleney K, Harding SE, Stetefeld J and McKenna SA.#

Journal of Biological Chemistry

View Article

21.

Recognition of viral RNA stem-loops by the tandem double-stranded RNA binding domains of PKR

Dzananovic E, Patel TR, Deo S, McEleney K, Stetefeld J and McKenna SA#

RNA

View Article

20.

Determination of a molecular shape for netrin-4 from hydrodynamic and small angle X-ray scattering measurements

Patel TR, Reuten R, Xiong S*, Meier M, Winzor DJ, Koch M and Stetefeld J#

Matrix Biology

View Article

19.

The macromolecular state of A-kinase anchoring protein

Patel TR# and Winzor DJ

Journal of Molecular Recognition

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18.

Site specific cleavage mediated by MMPs regulates function of agrin

Patel TR, Butler G, McFarlane A, Xie I*, Overall CM and Stetefeld J#

PLoS ONE

View Article

17.

T-shaped arrangement of the recombinant agrin G3-IgG Fc protein

Patel TR, Meier M, Li J, Morris G, Rowe AJ, Stetefeld J#

Protein Science

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16.

Reassessment of the size of the supermolecular state of Dishevelled-3

Patel TR#, Winzor DJ

Journal of Molecular Recognition

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15.

Examination of the discrepancy between size estimates for ovalbumin from small-angle X-ray scattering and other physicochemical measurements

Scott DJ, Patel TR, Besong DM, Stetefeld J, Winzor DJ#

Journal of Physical Chemistry B

View Article

14.

Evidence for self-association of a miniaturized version of agrin from hydrodynamic and small-angle X-ray scattering measurements

Patel TR##, Besong TM, Patel N, Meier M, Harding SE, Winzor DJ, Stetefeld J#

Journal of Physical Chemistry B

View Article

13.

Absence of a catalytic water confers resistance to the neurotoxin gabaculine

Orriss GL, Patel TR, Sorensen J, Stetefeld J##

FASEB Journal

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12.

Nano-structure of the laminin γ-1 short arm reveals an extended and curved multidomain assembly

Patel TR, Morris GA, Zwolanek D, Keene DR, Li J, Harding SE, Koch M, Stetefeld J#

Matrix Biology

View Article

11.

Vimentin coil 1A-A molecular switch involved in the initiation of filament elongation

Meier M, Padilla GP, Herrmann H, Wedig T, Hergt M, Patel TR, Stetefeld J, Aebi U, Burkhard P#

Journal of Molecular Biology

View Article

10.

Pectic polysaccharides from Biophytum petersianum Klotzsch, and their activation of macrophages and dendritic cells

Inngjerdingen M, Inngjerdingen KT, Patel TR, Allen S, Chen X, Rolsted B, Harding SE, Michaelsen TE, Diallo D, Paulsen BS#

Glycobiology

View Article

9.

Global hydrodynamic analysis of the molecular flexibility of galactomannans

Morris GA, Patel TR, Picout DR, Ross-Murphy SB, Ortega A, Garcia de la Torre J, Harding SE#

Carbohydrate Polymers

View Article

8.

Molecular flexibility of methylcelluloses of differing degree of substitution by combined sedimentation and viscosity analysis

Patel TR, Morris GA, Garcia de la Torre JG, Ortega A, Mischnick P, Harding SE#

Macromolecular Bioscience

View Article

7.

Global conformation analysis of irradiated xyloglucans

Patel TR, Ebringerová A, Vodeničarová M, Velebny V, Morris GA, Ortega A, Garcia de la Torre J, Harding SE#

Carbohydrate Polymers

View Article

6.

Immunological and structural properties of a pectic polymer from Glinus oppositifolius

Inngjerdingen KT, Patel TR, Chen X, Lennart K, Allen S, Morris GA, Harding SE, Matsumoto T, Diallo D, Yamada H, Michaelsen TE, Inngjerdingen M, Paulsen BS#

Glycobiology

View Article

5.

Weak self-association in a carbohydrate system

Patel TR, Harding SE, Ebringerova A, Deszczynski M, Hromadkova Z, Togola A, Paulsen BS, Morris GA, Rowe AJ#

Biophysical Journal

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4.

Structures and structure-activity relationships of three mitogenic and complement fixing pectic arabinogalactans from the Malian antiulcer plants Cochlospermum tinctorium A. Rich and Vernonia kotschyana Sch. Bip. ex Walp

Nergard CS, Kiyohara H, Reynolds JC, Thomas-Oates JE, Matsumoto T, Yamada H, Patel TR, Petersen D, Michaelsen TE, Diallo D, Paulsen BS#

Biomacromolecules

View Article

3.

Resonance energy transfer between green fluorescent protein variants: complexities revealed with myosin fusion proteins

Zeng W, Seward HE, Málnási-Csizmadia A, Wakelin S, Woolley RJ, Cheema GS, Basran J, Patel TR, Rowe AJ, Bagshaw CR#

Biochemistry

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2.

Damaged starch characterisation by ultracentrifugation

Tester RF, Patel TR, Harding SE#

Carbohydrate Research

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1.

Pressure cell assisted solution characterization of galactomannans. 3. Application of analytical ultracentrifugation techniques

Patel TR, Picout DR, Harding SE, and Ross-Murphy SB#

Biomacromolecules

View Article

2025

Structural dynamics of dengue virus UTRs and their cyclization

Global distribution of microbial carrageenan foraging pathways reveals latent traits within the genetic dark matter of ruminant intestinal microbiomes

Zyxin directly binds to chromosomal DNA and regulates the expression of mitochondrial pseudogenes, mitochondrial integrity and apoptosis in prostate cancer

Solution Structure Determination and Biophysical Studies of 7SK RNP and 7SL SRP RNAs

Discovery of functional factor-less internal ribosome entry site-like structures through virome mining

Alu RNA pseudoknot alterations influence SRP9/SRP14 association

Characterization of Biomolecular Interactions by Biophysical Methods

Development of Low-Cost In-House Assays for Quantitative Detection of HBsAg, HBeAg, and HBV DNA to Enhance Hepatitis B Virus Diagnostics and Antiviral Screening in Resource-Limited Settings

Suppressing Tymovirus replication in plants using a variant of ubiquitin

2024

Regional Medical Campuses in Canada: Exploring the Landscape of Current and Proposed Campuses

In vitro and ex vivo metabolism of chemically diverse fructans by bovine rumen Bifidobacterium and Lactobacillus species

Analysis of the interlink between glucose-6-phosphate dehydrogenase (G6PD) and lung cancer through multi-omic databases

Assessment of HBV variants and novel viral and immune biomarkers in chronic 2 hepatitis B patients with metabolic-dysfunction associated steatotic liver disease

Factor-dependent internal ribosome entry site and -1 programmed frameshifting signal in the Bemisia-associated dicistrovirus 2

Development of a single-domain antibody to target a G-quadruplex located on the hepatitis B virus covalently closed circular DNA Genome

Zika virus remodels and hijacks IGF2BP2 ribonucleoprotein complex to promote viral replication organelle biogenesis

2023

tRNA shape is an identity element for an archaeal pyrrolysyl-tRNA synthetase from the human gut

The 3' terminal region of Zika virus RNA contains a conserved G-quadruplex and is unfolded by human DDX17

Genomic Mapping and Characterization of G-quadruplexes in Monkeypox Genomes

Investigating RNA-RNA interactions through computational and biophysical analysis

2022

A comprehensive review of methods to study lncRNA-protein interactions in solution

Purification and Characterization of Inorganic Pyrophosphatase for in vitro RNA Transcription

Biophysical Characterisation of Human LincRNA-p21 Sense and Antisense Alu Inverted Repeats

Targeting Xist with compounds that disrupt RNA structure and X-inactivation

2021

Molecular mechanism of quorum sensing inhibition in Streptococcus by the phage protein paratox

Identification and characterization of a G-quadruplex structure in the pre-core promoter region of hepatitis B virus covalently closed circular DNA

Bioinformatic Analysis of Structure and Function of LIM Domains of Human Zyxin Family Proteins

Human DDX3X unwinds Japanese Encephalitis and Zika viral 5' Terminal Regions

Biophysical Characterisation of G-quadruplex Nucleic Acids Using Top-Down and Bottom-Up Approaches

2020

Molecular characterization of the programmed ribosomal frameshifting complex generated by Porcine Reproductive and Respiratory Syndrome Virus

Analytical ultracentrifuge: An ideal tool for characterization of non-coding RNAs

Molecular Mechanisms of Viral Hepatitis Induced Hepatocellular Carcinoma

Biodefense implications of New-World Hantaviruses

Structural and hydrodynamic characterization of dimeric human oligoadenylate synthetase 2

The biomedical and bioengineering potential of protein nanocompartments

Nanoscale structure determination of Murray Valley encephalitis and Powassan virus non-coding RNAs

Host transcription factors in Hepatitis B Virus RNA synthesis

Solution structure and oligomeric state of the E. coli glycerol facilitator

Canadian Science Meets Parliament: Building Relationships Between Scientists and Policymakers

Current approaches for RNA labelling to identify RNA-binding proteins

Zinc-finger protein CNBP alters the 3-D structure of lncRNA Braveheart in solution

Asparagine-84, a regulatory allosteric site residue, helps maintain the quaternary structure of Campylobacter jejuni dihydrodipicolinate synthase

2019

Experimental determination of second virial coefficients by small-angle X-ray Scattering: a problem revisited

Use of molecular crowding for the detection of protein self-association by size-exclusion chromatography

Solution structure of C. elegans UNC-6: A nematode paralogue of the axon guidance protein netrin-1

Crystal structure of the TreS-Pep2 complex, initiating α-glucan synthesis in the GlgE pathway of mycobacteria

Microscale thermophoresis: Warming up to a new biomolecular interaction technique

A cholesterol analog induces an oligomeric reorganization of VDAC

Proceedings of the Canadian Association for HIV Research – Canadian Foundation for Infectious Diseases Professional Development Workshop for Viral Researchers

2018

Comprehensive analysis of hepatitis B virus promoter region mutations

Structural studies of macromolecules in solution using small angle X-Ray scattering

The role of zyxin in regulation of malignancies

Viral proteins targeting host protein kinase R to evade an innate immune response: a mini review

DEAD-box helicases: The Yin and Yang roles in viral infections

Structure and hydrodynamics of a DNA G-quadruplex with a cytosine bulge

Non-coding RNAs in Virology: an RNA Genomics Approach

Interaction studies of a protein and carbohydrate system using an integrated approach: a case study of miniagrin - heparin system

2017

Intrinsic disorder in the partitioning protein KorB persists after co-operative complex formation with operator DNA and KorA

Nanoscale assembly of high-mobility group AT-hook 2 protein with DNA replication fork

Allowance for radial dilution in evaluating the concentration dependence of sedimentation coefficients for globular proteins

Impact of the structural integrity of the three-way junction of adenovirus VAI RNA on PKR inhibition

Inhibition of glycosylation on a camelid antibody uniquely affects its FcγRI binding activity

2016

Structural studies of RNA-protein complexes: A hybrid approach involving hydrodynamics, scattering, and computational methods

Regulation of platelet derived growth factor signaling by leukocyte common antigen-related (LAR) protein tyrosine phosphatase: A quantitative phosphoproteomics study

Structural decoding of netrin-4 reveals a regulatory function towards mature basement membranes

Dynamic light scattering: A practical guide and applications in biomedical sciences

LAR protein tyrosine phosphatase regulates focal adhesions through CDK1

Application of novel analytical ultracentrifuge analysis to solutions of fungal mannans

Structural decoding of the netrin-1/UNC5 interaction and its therapeutical implications in cancers